Nevertheless, there have been no considerable discrepancies in bone mineral density with the lumbar spine or proximal femur among any with the treatment groups. The authors noted the significance of taking into consideration the effect of vitamin D on bone health and fitness when comparing the outcomes of vitamin K supplementation reports, particularly when both equally vitamin K and vitamin D (and/or calcium) are administered for the cure team although not the placebo group [38]. The administration of vitamin D and/or calcium along with vitamin K could partly make clear why some research have discovered that vitamin K supplementation increases bone health and fitness while some haven't.

While vitamin K is linked to the carboxylation of osteocalcin, it is unclear no matter if supplementation with any form of vitamin K lessens the chance of osteoporosis. In 2006, Cockayne and colleagues conducted a scientific evaluation and meta-Investigation of randomized controlled trials that examined the consequences of vitamin K supplementation on bone mineral density and bone fracture [35]. The vast majority of trials had been carried out in Japan and included postmenopausal Ladies; trial duration ranged from six to 36 months.

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Due to the fact vitamin K is required for the carboxylation of osteocalcin in bone, vitamin K deficiency could also reduce bone mineralization and lead to osteoporosis [23].

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